High Potassium Levels And Elevated BUN And Creatinine In Nephrotic Syndrome

BUN and creatinine, both are the important indicators of nephrotic syndrome to reflect how well the kidney function works. 
Your kidneys help maintain normal blood concentration by removing wastes, excess fluid and electrolytes such as potassium. Potassium, blood urea nitrogen, or BUN, and creatinine blood tests can monitor kidney function in Nephrotic Syndrome patients diagnosed with kidney disease. High potassium levels in the blood, elevated BUN and elevated creatinine in Nephrotic Syndrome are all indicators of some degree of kidney dysfunction.
Creatinine
Your muscles use a compound called creatine in order to contract. Every time your muscles contract, creatine is broken down and a waste product called creatinine is produced. This creatinine enters your blood and travels to your kidneys, where almost all of it is removed by your kidneys. A normal blood creatinine level falls between 0.8 to 1.4 mg/dL. Elevated levels of creatinine in the blood in nephrotic syndrome indicate that the kidneys are not functioning normally.
BUN
When you eat protein, your body breaks it down into its building blocks, which are called amino acids. When protein is broken down, a waste product called nitrogen is produced in the liver. This nitrogen combines with other molecules to create another waste product called urea. Urea then enters the bloodstream where the kidneys remove it from the body through your urine. A healthy individual has very small amounts of urea in the blood. When the kidneys are not functioning properly, they do not remove urea, and levels accumulate in the blood. A blood urea nitrogen, or BUN, test measures the amount of urea in your blood. A healthy BUN usually falls between 7 and 20 mg/dL. If your BUN level exceeds 20 mg/dL, it can indicate kidney disease.
Potassium
The most common cause of high potassium in the blood, or hyperkalemia in nephrotic syndrome, is kidney disease, according to MayoClinic.com. Most of the potassium in your body is found inside of your cells, although a small amount circulates throughout your body in your blood. A healthy blood potassium level falls between 3.6 and 4.8 mEq/L. Normally, your kidneys maintain tight control of the level of potassium in your blood by filtering excess potassium from the blood when needed. When your kidneys are not working properly, they do not remove potassium from the blood efficiently, causing levels to increase above 4.8 mEq/L.
Considerations
Although potassium, BUN and creatinine tests can determine if your kidneys are not functioning normally, they cannot isolate the cause of the kidney dysfunction. Abnormal values can occur as a result of acute kidney failure, chronic kidney failure, glomerulonephritis and urinary tract obstruction. If your lab values come back abnormal, your doctor may recommend further testing to isolate the cause of your kidney disease.
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