Fish oil contains omega-3 fatty acids. There are two different types of omega-3 fatty acids: EPA and DHA.
Fish oil is NOT the same as cod liver oil or halibut liver oil. These fish liver oils contain large amounts of vitamin A. Large amounts of vitamin A are not recommended for people with kidney disease.
Why did my doctor prescribe or recommend it?
You have a kidney disease called IgA Nephropathy. Most people with this condition maintain normal kidney function. However, in some patients (about 30%), kidney function may get worse over time. Your doctor (nephrologist) thinks you may be one of those people whose kidneys may worsen over the years. Fish oil therapy may prevent or slow down the worsening.
Is it Effective?
Fish oil is used to slow the progression of kidney disease in people with IgA nephropathy. While fish oil capsules may be effective in many patients, some patients do not respond to it.
How does it work?
The omega-3 fatty acids in fish oil prevent inflammation in the kidney to slow down progression of kidney disease.
How will you know if it is working?
Your blood tests may show a decrease in the creatinine level (creatinine measures kidney function). Please note that fish oil does not usually decrease the amount of protein in the urine. Certain blood pressure pills and prednisone pills are used to decrease protein in the urine.
An additional benefit is that fish oil may lower the level of fats called triglycerides in your
Are there safety concerns?
Fish oil is generally safe and most people do not experience any side effects. Others may
notice belching, fishy-smelling breath, heartburn or diarrhea. Taking your fish oil capsules with meals can decrease these side effects.
Are there any interactions with medications?
Medications that slow blood clotting (e.g. aspirin, clopidogrel (Plavix® ), warfarin (Coumadin®)):
Fish oils may slow blood clotting. Taking fish oils along with medications that also slow clotting may increase the chances of bruising and bleeding.
Medications for high blood pressure:
Fish oils may decrease blood pressure. Taking fish oils along with medications for high blood pressure may cause your blood pressure to go too low. Fish oil also might improve your blood pressure if it is too high. Good blood pressure control is an important part of treating IgA nephropathy. Target blood pressure for people with kidney disease is 130/80mm Hg or lower.
What doses are recommended?
We recommend that you take a total of 1000-1200 mg DHA and 1800-2000 mg EPA. This means taking 5-10 capsules of fish oil each day.
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